Inhibition by lomofungin of nucleic acid and protein synthesis inSaccharomyces cerevisiae
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Lomofungin as an Inhibitor of Nucleic Acid Synthesis in Saccharomyces cerevisiae
1. The antibiotic lomofungin was found to be a potent inhibitor of both DNA and RNA synthesis in Saccharomyces cerevisiae. Underselected growth conditions inhibition ofDNA synthesis by the drug preceded inhibition of RNA synthesis. 2. Although in general lomofungin inhibited synthesis ofribosomalRNA and polydisperseRNA more effectively than that of low-molecular-weight RNA, under certain condit...
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Woolley and Pringle (13) have recently reported the formation of 4-amino-5-carboxamidoimidazole during growth of Escherichia coli in the presence of 4-aminopteroylglutainic acid (aminopterin). Some of us have observed that excessive doses of folie acid speed up the leukemic process in mice and that folie acid will reverse the well known antileukemic action of aminopterin (11). This reversal of ...
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2 Roberg, M., Jahrb f. wiss. Bot., 83, 567 (1936). 3 Burk, D., Biokhimiya, 2, 312 (1937). 4 Burris, R. H., F. J. Eppling, H. B. Wahlin, and P. W. Wilson, J. Biol. Chem., 148, 349 (1943). 5 Hamilton, P. G., W. E. Magee, and L. E. Mortenson, Bact. Proc., 82 (1953). 6 Burris, R. H., in Inorganic Nitrogen Metabolism, ed. W. D. McElroy and B. Glass (Baltimore: Johns Hopkins Press, 1956), p. 316. 7 M...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1973
ISSN: 0014-5793
DOI: 10.1016/0014-5793(73)80852-x